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TAK-003 Structure
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Immune Responses

Review the Takeda Vaccine’s sponsored publications to learn about the immune responses to TAK-003.

Innate Responses

Explore the effects of TAK-003 on the innate immune system, including the type I interferon response.

Immune Response

Neutralizing antibodies

Dengue virus infection reprograms baseline innate immune gene expression

Ong, et al. 2025

VV-MEDMAT-133702

Immune Response

TAK-003 structure

Development of a recombinant, chimeric tetravalent dengue vaccine candidate

Osorio JE, et al. Vaccine. 2015

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Humoral Responses

Review the impact of TAK-003 on the humoral immune response.

Immune Response

TAK-003 structure

Development of a recombinant, chimeric tetravalent dengue vaccine candidate

Osorio JE, et al. Vaccine. 2015

VV-MEDMAT-119468

1/2

Cellular Responses

Read about the cell-mediated immune response following TAK-003 vaccination.

Immune Response

Humoral and cellular responses to a tetravalent dengue vaccine (TAK-003) in adults from a dengue non-endemic region: An open-label phase 2 trial

Mandaric, et al. 2026

VV-MEDMAT-133702

Immune Response

Neutralizing antibodies

Dengue virus infection reprograms baseline innate immune gene expression

Ong, et al. 2025

VV-MEDMAT-133702

Immune Response

T-cell response

Long term T cell response and safety of a tetravalent dengue vaccine in healthy children

Mandaric S, et al. NPJ Vaccines. 2024

VV-MEDMAT-119468

Immune Response

T-cell response

Reply to: Editorial “The increasing use of T-cell stimulation for successful dengue vaccination” in eBioMedicine 2024; 102, 105120

Kandeil W, et al. eBioMedicine. 2024

VV-MEDMAT-119468

Immune Response

T-cell response

Characterization of the cell-mediated immune response to Takeda's live-attenuated tetravalent dengue vaccine in adolescents participating in a phase 2 randomized controlled trial conducted in a dengue-endemic setting

Tricou V, et al. Vaccine. 2022

VV-MEDMAT-119468

Immune Response

TAK-003 structure

A recombinant, chimeric tetravalent dengue vaccine candidate based on a dengue virus serotype 2 backbone

Osorio JE, et al. Expert Rev Vaccines. 2016

VV-MEDMAT-119468

Immune Response

TAK-003 structure

Development of a recombinant, chimeric tetravalent dengue vaccine candidate

Osorio JE, et al. Vaccine. 2015

VV-MEDMAT-119468

Immune Response

T-cell response

CD8+ T-cell responses in flavivirus-naïve individuals following immunization with a live-attenuated tetravalent dengue vaccine candidate

Chu H, et al. J Infect Dis. 2015

VV-MEDMAT-119468

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Explore the TAK-003 Clinical
Program Efficacy & Safety Data

Clinical Program Efficacy & Safety Data

Cellular Response

Learn more about the effects of TAK-003 on the cellular immune response

HUMORAL Response

Review the impact of TAK-003 on the humoral immune response.

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Innate Response

Learn more about the effects of TAK-003 on the innate immune response

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All Publications
TAK-003 Structure
Immune Responses
Clinical Program Efficacy & Safety Data
Search
Contact Medical Information

This website contains Takeda-sponsored publications only.

Visit the Dengue Academy for educational resources on dengue. Dengue Academy is an educational website for healthcare professionals intended for informational purposes only. It covers general topics like dengue epidemiology, diagnosis, burden and control. This website is also initiated and developed by Takeda.

This information is solely intended for the use of Registered Healthcare Practitioner / Registered Medical Practitioner only. The information contained herein is based on the published medical literature and international recommended guidelines. The information provided is intended for educational purposes only, aimed at increasing awareness on Dengue disease and not meant for promotion of any specific product. Registered Healthcare Practitioner / Registered Medical Practitioner shall apply their independent medical judgement for diagnosing or assessing or treating any patient. Takeda makes no representation or warranty concerning the information / content provided and assumes no responsibility for the accuracy of the of the information or content or opinion furnished, or any outcome based on the application of such information. This material contains copyright protected information, content; the use of which is limited by law and this material cannot be reproduced, replicated, used or modified by any person for their own use or further distribution.

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Document Number: C-ANPROM/IN/QDE/0045; Date of Preparation: December 2025

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